Overview

This is the analysis of white matter dsi studio connectometry for Maze and Loop

Methods

Participants

  • Total number of scans = 120 (males and females)

  • Total scans used in analysis= 118

  • Excluded subs 329 and 372 from analyses due to bad behavior data and Subject 347 failed quality control check in DSI

  • Several subjects removed because they did not have rad3 score

Loop: Position Error, Degree Error, Angular Error

  • Rad 3
    • All subjects: 38
    • Men: 14
    • Women: 24
    • Stage:
      • Pre: 10
      • Peri: 7
      • Post: 7
  • Average
    • All subjects: 42
    • Men: 17
    • Women: 25
    • Stage:
      • Pre: 11
      • Peri: 7
      • Post: 7

Scan parameters

  • Locations from UCSB and UCI

QSIprep

  • Version used: 0.16.0RC3

  • The following parameters were used

    • dwi_denoise_window 5
    • hmc_model 3dSHORE
    • hmc-transform Rigid
    • shoreline_iters 2
      DSI Studio

  • Version and tags used via singularity container: chen-2022-07-31

  • Parameters

    • T-threshold = 2.5
    • Length = 25
    • Permutation = 4,000
    • pruning 4
    • non normalized QA
Connectronomy analysis methods write up
A diffusion spectrum imaging scheme was used, and a total of 128 diffusion sampling were acquired.The maximum b-value was 4990 s/mm². The in-plane resolution was 1.8 mm. The slice thickness was 1.8 mm. The accuracy of b-table orientation was examined by comparing fiber orientations with those of a population-averaged template (Yeh et al. Neuroimage, 2018). The b-table was flipped by. The diffusion data were reconstructed in the MNI space using q-space diffeomorphic reconstruction (Yeh et al., Neuroimage, 58(1):91-9, 2011) to obtain the spin distribution function (Yeh et al., IEEE TMI, ;29(9):1626-35, 2010). A diffusion sampling length ratio of 1.25 was used. The output resolution in diffeomorphic reconstruction was 1.8 mm isotropic. The tensor metrics were calculated using DWI with b-value lower than 1750 s/mm². The quantitative anisotropy was extracted as the local connectome fingerprint (LCF, Yeh et al. PLoS Comput Biol 12(11): e1005203) and used in the connectometry analysis.


Diffusion MRI connectometry (Yeh et al. NeuroImage 125 (2016): 162-171) was used to derive the correlational tractography that has QA, MD, AD, and RD correlated with Maze Accuracy and Loop variables. A nonparametric Spearman partial correlation was used to derive the correlation, and the effect of sex, age_scan_years, and repo_status was removed using a multiple regression model. The total number of subjects varied on analysis (See Analyses and Final sample sizes above). A T-score threshold of 2.5 was assigned and tracked using a deterministic fiber tracking algorithm (Yeh et al. PLoS ONE 8(11): e80713, 2013) to obtain correlational tractography. A seeding region was placed at whole brain (39,49,29) .

The tracks were filtered by topology-informed pruning (Yeh et al. Neurotherapeutics, 16(1), 52-58, 2019) with 4 iteration(s). A length threshold of 25 voxel distance was used to select tracks. To estimate the false discovery rate, a total of 4000 randomized permutations were applied to the group label to obtain the null distribution of the track length.




Behavior

Angular error is the degree difference btween the start location and the end location. Participants were tested on three different sizes of circles: Radius 1m, 2m, and 3m. For white matter analysis we used the data from radius 3 and an average of performance on all three circle sizes. The average position error on the 1m circle is 47.6146335. The average position error on the 2m circle is 56.1275526. The average position error on the 3m circle is 68.3846003. The average position error across all sizes is 56.4495802.

There are were significant differences in performance between men and women on the rad3 loop (t test, p= 0.50858) and on the average of all circles ( p = 0.4163938). The mean distance for degrees traveled in men on the rad3 circle was 64.924295, and in women it was 70.4031117. Men undershot the target location while women overshot the location The mean for the average of all circles in men is 51.2907976 and women is 59.9575524.

The average for degrees traveled on rad3
pre = 71.073026

peri = 73.2993367

post = 71.0431529

The average for degrees traveled on average of all circles
pre = 62.239975

peri = 63.5120417

post = 55.5092757





Results


Loop angular error Rad3

QA

All subjects

Positive Correlations (FDR = 0.000675)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 877 55.9796 12.0679 6403
Cerebellum_L 64 53.1643 4.58556 878
Fornix_R 12 52.1689 2.5954 276
Cingulum_Frontal_Parietal_L 10 52.4089 1.953 157



Negative Correlations (FDR = 0.004296)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corticospinal_Tract_R 304 55.1267 8.55124 3166
Arcuate_Fasciculus_R 182 52.5773 5.35013 1182
Medial_Lemniscus_R 52 56.3921 4.97225 1095
Corpus_Callosum_Tapetum 23 52.788 3.23916 435



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop Angular error rad3


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop angular error rad3


Glass Brain displaying tracts that had QA positively and negatively correlated with loop angular error rad3







Men

Positive Correlations (FDR = 0.012481)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 994 58.7371 13.4206 8309
Cerebellum_L 631 56.935 10.6459 5068
Cerebellum_R 249 53.6912 9.48158 3791
Corticospinal_Tract_R 238 59.1276 7.75247 2791
Corpus_Callosum_Tapetum 170 59.6702 9.6741 4386
Arcuate_Fasciculus_L 159 55.8202 7.70542 2603
Inferior_Fronto_Occipital_Fasciculus_R 156 57.063 6.75498 2045
Corpus_Callosum_Body 154 59.7992 9.43738 4183
Superior_Longitudinal_Fasciculus2_R 129 56.3811 7.73299 2648
Arcuate_Fasciculus_R 116 57.8156 7.73957 2720
Superior_Longitudinal_Fasciculus3_R 96 60.4046 6.44723 1972
Medial_Lemniscus_R 90 56.6319 6.76737 2037
Corticostriatal_Tract_Superior_R 69 55.5161 5.76474 1449
Vermis 63 53.215 5.77937 1396
Corpus_Callosum_Forceps_Major 59 62.0339 6.02566 1769
Cingulum_Frontal_Parietal_L 53 61.7079 3.18616 492
Inferior_Longitudinal_Fasciculus_R 51 54.9511 5.04392 1098
Corticopontine_Tract_Parietal_R 50 60.2026 5.63052 1499
Thalamic_Radiation_Posterior_L 47 54.3075 5.31519 1205
Middle_Cerebellar_Peduncle 47 67.1561 4.36728 1006
Corticopontine_Tract_Parietal_L 39 57.7474 5.65617 1451
Corticostriatal_Tract_Posterior_L 38 65.009 5.66576 1639
Thalamic_Radiation_Anterior_R 34 57.6071 3.81935 660
Corticostriatal_Tract_Posterior_R 33 55.2883 5.01246 1091
Inferior_Fronto_Occipital_Fasciculus_L 18 55.2274 3.66302 582
Parietal_Aslant_Tract_L 18 61.678 2.37395 273
Cingulum_Frontal_Parahippocampal_L 15 57.4842 2.63722 314
Cingulum_Parolfactory_L 13 65.2353 2.72336 380
Extreme_Capsule_R 13 53.9993 3.22829 442
Frontal_Aslant_Tract_R 13 54.6191 3.28883 464
Dentatorubrothalamic_Tract_R 13 52.9296 2.95094 362



Negative Correlations (FDR = 0.024096)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 116 55.5436 7.63954 2546



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop Angular error rad3 in men

Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop angular error rad3 in men

Glass Brain displaying tracts that had QA positively and negatively correlated with loop angular error rad3 in men







Women

Positive Correlations (FDR = 0.015385)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 35 54.407 3.71266 589



Negative Correlations (FDR = 0.001027)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corticospinal_Tract_R 239 55.4744 7.1526 2229
Arcuate_Fasciculus_R 114 54.341 4.77717 974
Medial_Lemniscus_R 95 57.0645 4.7495 1011
Corpus_Callosum_Tapetum 60 54.4736 4.43891 843
Inferior_Longitudinal_Fasciculus_R 25 57.4453 3.14057 445
Corticostriatal_Tract_Superior_R 20 53.9077 3.42961 498
Cingulum_Frontal_Parietal_L 16 53.6303 2.50826 265
Dentatorubrothalamic_Tract_R 15 51.746 3.22617 423



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop Angular error rad3 in women


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop angular error rad3 in women

Glass Brain displaying tracts that had QA positively and negatively correlated with loop angular error rad3 in women







pre

Positive Correlations (FDR = 0.036981)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 532 62.1823 10.7882 5684
Corpus_Callosum_Tapetum 438 55.1425 11.7919 6022
Corpus_Callosum_Body 346 59.1443 9.77555 4439
Cerebellum_L 155 55.1539 7.57713 2487
Corpus_Callosum_Forceps_Minor 134 57.2479 7.07245 2249
Fornix_L 60 61.0718 4.38192 921
Fornix_R 57 56.4362 3.77901 633
Arcuate_Fasciculus_L 50 54.402 3.53524 534
Inferior_Longitudinal_Fasciculus_L 27 56.5924 5.23694 1219
Thalamic_Radiation_Posterior_L 24 53.8504 4.31094 786
Corticostriatal_Tract_Posterior_L 20 54.8058 3.57456 550
Cingulum_Frontal_Parietal_R 14 62.1548 2.87679 404



Negative Correlations (FDR = 0.009185)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Inferior_Fronto_Occipital_Fasciculus_R 510 63.0641 9.04814 4055
Corticospinal_Tract_L 271 57.1097 11.0875 5514
Inferior_Fronto_Occipital_Fasciculus_L 262 56.5833 7.10437 2243
Corticospinal_Tract_R 251 58.6942 8.60702 3415
Cerebellum_L 222 56.1792 7.86447 2729
Cingulum_Frontal_Parietal_L 204 55.5582 6.13807 1644
Middle_Cerebellar_Peduncle 174 55.7707 8.49636 3162
Corpus_Callosum_Tapetum 162 60.7 7.25022 2506
Inferior_Longitudinal_Fasciculus_R 148 58.2545 5.78277 1530
Arcuate_Fasciculus_L 117 58.4216 7.03056 2268
Medial_Lemniscus_L 114 57.2181 7.15872 2303
Corticostriatal_Tract_Superior_L 107 56.5335 8.3584 3102
Medial_Lemniscus_R 80 55.1851 6.23326 1684
Dentatorubrothalamic_Tract_L 70 55.1835 7.00213 2125
Cingulum_Parolfactory_R 69 59.4306 3.99242 744
Arcuate_Fasciculus_R 64 60.978 6.21183 1848
Superior_Longitudinal_Fasciculus2_R 64 56.7607 5.33534 1269
Cingulum_Frontal_Parietal_R 62 55.4943 5.40012 1271
Corpus_Callosum_Body 53 54.5364 5.5849 1336
Uncinate_Fasciculus_R 51 56.2061 4.06932 731
Vermis 50 53.4535 4.85852 991
Corticopontine_Tract_Parietal_L 49 65.4395 4.3711 982
Superior_Longitudinal_Fasciculus2_L 40 55.5082 5.31812 1233
Cingulum_Frontal_Parahippocampal_L 36 53.5589 3.89753 639
Dentatorubrothalamic_Tract_R 36 55.5621 5.1089 1139
Extreme_Capsule_L 18 59.1259 3.47884 562
Cingulum_Frontal_Parahippocampal_R 15 56.408 2.66649 315
Corticopontine_Tract_Parietal_R 13 60.3215 3.60294 615
Extreme_Capsule_R 12 53.1778 2.41705 244
Corpus_Callosum_Forceps_Major 12 62.6695 2.78586 382
Superior_Longitudinal_Fasciculus3_L 10 53.0228 2.9928 373
Corticostriatal_Tract_Posterior_R 10 54.2202 3.2795 458



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop Angular error rad3 in pre menopausal women


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop angular error rad3 in pre menopausal women


Glass Brain displaying tracts that had QA positively and negatively correlated with loop angular error rad3 in pre menopausal women







peri

Positive Correlations (FDR = 0.317868)
No Significant Findings



Negative Correlations (FDR = 0.029057)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 330 65.9288 14.8677 11446
Corticospinal_Tract_R 247 65.1614 10.797 5966
Inferior_Fronto_Occipital_Fasciculus_R 237 62.9996 11.1414 6142
Corpus_Callosum_Tapetum 230 64.0876 12.4875 7849
Cerebellum_L 226 55.824 13.6766 8201
Superior_Longitudinal_Fasciculus2_R 222 63.6687 11.0012 6052
Arcuate_Fasciculus_R 217 68.5276 10.5223 5959
Middle_Cerebellar_Peduncle 194 61.8863 11.7635 6726
Corpus_Callosum_Forceps_Major 165 60.5409 10.4133 5156
Cingulum_Frontal_Parietal_R 164 67.6788 8.10524 3492
Corticostriatal_Tract_Posterior_R 164 65.9497 10.4386 5644
Arcuate_Fasciculus_L 156 58.5221 10.6119 5176
Dentatorubrothalamic_Tract_R 132 60.3919 10.8337 5567
Medial_Lemniscus_R 117 64.7779 8.32734 3528
Cerebellum_R 112 54.0119 11.2533 5372
Inferior_Fronto_Occipital_Fasciculus_L 107 63.858 8.71128 3806
Inferior_Longitudinal_Fasciculus_L 103 61.2768 8.57526 3539
Inferior_Longitudinal_Fasciculus_R 99 60.4508 9.74312 4507
Corticostriatal_Tract_Posterior_L 83 60.9943 8.90054 3795
Corticospinal_Tract_L 82 62.5653 7.91577 3079
Frontal_Aslant_Tract_L 80 61.3321 8.23794 3269
Corticopontine_Tract_Parietal_R 80 62.2362 7.68523 2887
Superior_Longitudinal_Fasciculus2_L 78 60.0313 8.49067 3399
Dentatorubrothalamic_Tract_L 77 58.3208 8.58 3372
Corticostriatal_Tract_Superior_L 65 57.147 8.1058 2949
Thalamic_Radiation_Posterior_R 63 60.3866 7.08243 2379
Thalamic_Radiation_Anterior_R 62 66.3354 6.61821 2282
Cingulum_Frontal_Parietal_L 58 60.6987 6.36768 1933
Corticostriatal_Tract_Superior_R 58 62.875 7.70151 2929
Corpus_Callosum_Forceps_Minor 58 61.6993 7.08284 2431
Medial_Lemniscus_L 56 58.516 6.31193 1831
Vermis 56 56.2245 6.62987 1941
Thalamic_Radiation_Superior_R 50 64.7278 7.14598 2596
Superior_Longitudinal_Fasciculus1_R 49 65.5205 5.81321 1739
Anterior_Commissure 45 65.2566 6.16506 1948
Extreme_Capsule_R 42 62.6303 5.72815 1614
Cingulum_Parahippocampal_Parietal_R 40 56.8632 5.66649 1434
Corticopontine_Tract_Parietal_L 38 65.4282 6.00172 1851
Reticular_Tract_R 36 62.3961 6.4393 2032
Superior_Longitudinal_Fasciculus3_R 31 60.652 5.2899 1333
Parietal_Aslant_Tract_L 29 58.9126 4.83128 1080
Corticopontine_Tract_Frontal_R 29 58.1488 5.48102 1372
Cingulum_Parolfactory_R 25 66.169 4.14528 893
Middle_Longitudinal_Fasciculus_R 23 58.529 5.07082 1182
Thalamic_Radiation_Posterior_L 22 58.7316 5.03631 1170
Extreme_Capsule_L 20 63.405 4.68279 1092
Optic_Radiation_L 17 55.7674 3.51125 540
Superior_Longitudinal_Fasciculus3_L 16 59.756 4.44671 928
Corticopontine_Tract_Occipital_R 16 64.6266 3.27979 546
Reticular_Tract_L 16 64.0179 4.49301 1015
Frontal_Aslant_Tract_R 13 53.6847 4.01 678
Parietal_Aslant_Tract_R 13 57.8639 3.78188 650
Corticopontine_Tract_Frontal_L 12 67.5064 3.65684 709
Cingulum_Parolfactory_L 11 60.1934 2.12261 213
Thalamic_Radiation_Superior_L 11 62.7421 3.76899 700
Cingulum_Frontal_Parahippocampal_R 10 68.0192 3.07153 504
Middle_Longitudinal_Fasciculus_L 10 56.2141 3.62761 581



Figures

Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop angular error rad3 in peri menopausal women

Glass Brain displaying tracts that had QA negatively correlated with loop angular error rad3 in peri menopausal women







post

Positive Correlations (FDR = 1.000000)
No Significant Findings



Negative Correlations (FDR = 0.302332)
No Significant Findings











Peri + Post

Positive Correlations (FDR = 0.082506)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 681 58.7354 11.7131 6329
Corpus_Callosum_Body 366 56.2798 12.6399 7062
Middle_Cerebellar_Peduncle 306 59.0543 10.7821 5392
Corpus_Callosum_Forceps_Major 173 61.4656 7.70776 2868
Corpus_Callosum_Tapetum 157 54.9597 8.07268 2813
Inferior_Fronto_Occipital_Fasciculus_R 83 55.7638 6.1006 1630
Uncinate_Fasciculus_R 55 57.9419 4.89184 1089
Cingulum_Frontal_Parietal_L 47 56.1396 3.59549 570
Cerebellum_L 42 53.2038 3.941 649
Cingulum_Frontal_Parietal_R 40 58.206 4.37497 875
Cingulum_Parolfactory_L 32 53.8777 2.88008 351
Cingulum_Parolfactory_R 29 57.8008 2.84716 368
Inferior_Longitudinal_Fasciculus_R 14 52.2868 2.95257 358
Thalamic_Radiation_Anterior_R 13 55.0804 3.24311 455



Negative Correlations (FDR = 0.081279)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 920 66.7952 14.7981 11488
Corpus_Callosum_Body 803 65.7615 16.6946 14395
Corpus_Callosum_Forceps_Major 538 70.7981 12.2352 8324
Cerebellum_R 495 56.2048 13.646 8220
Corpus_Callosum_Tapetum 404 63.2638 12.3203 7542
Corticospinal_Tract_R 392 62.4423 8.81294 3809
Arcuate_Fasciculus_L 222 56.3231 9.9914 4416
Inferior_Fronto_Occipital_Fasciculus_L 207 62.323 8.92155 3896
Medial_Lemniscus_R 167 57.1932 8.1491 2983
Inferior_Longitudinal_Fasciculus_L 149 62.3197 7.67076 2880
Corticostriatal_Tract_Superior_R 98 55.2739 6.75859 1983
Corticostriatal_Tract_Posterior_L 83 63.6939 8.10229 3284
Thalamic_Radiation_Posterior_R 79 59.1474 6.56477 2002
Cerebellum_L 75 54.2486 7.18739 2201
Corticospinal_Tract_L 74 59.3102 6.48496 1959
Superior_Longitudinal_Fasciculus2_R 73 57.1082 5.34 1279
Thalamic_Radiation_Posterior_L 67 57.5649 6.86221 2129
Corticostriatal_Tract_Posterior_R 64 58.229 6.87087 2159
Cingulum_Frontal_Parietal_L 62 61.1051 5.84037 1637
Middle_Longitudinal_Fasciculus_R 62 54.7522 6.35008 1734
Cingulum_Frontal_Parietal_R 58 57.013 5.1378 1182
Inferior_Fronto_Occipital_Fasciculus_R 54 55.2686 6.21744 1678
Corticostriatal_Tract_Superior_L 50 53.9601 5.27443 1179
Extreme_Capsule_L 49 59.56 5.9696 1667
Arcuate_Fasciculus_R 40 56.4534 5.1632 1182
Extreme_Capsule_R 40 56.0137 4.54058 907
Corticopontine_Tract_Parietal_R 34 58.8266 5.97962 1652
Middle_Longitudinal_Fasciculus_L 33 56.3185 4.13692 757
Cingulum_Parolfactory_L 31 58.2019 4.34502 863
Medial_Lemniscus_L 30 56.7371 4.62938 955
Dentatorubrothalamic_Tract_R 28 53.5793 5.02364 1062
Corticopontine_Tract_Parietal_L 24 59.4321 5.07032 1200
Thalamic_Radiation_Anterior_R 24 59.1752 4.15147 801
Superior_Longitudinal_Fasciculus1_L 19 56.8632 3.08122 424
Corticostriatal_Tract_Anterior_L 19 54.2121 3.74137 596
Dentatorubrothalamic_Tract_L 19 53.5778 4.12783 717
Cingulum_Parolfactory_R 18 57.7912 2.75298 344
Thalamic_Radiation_Anterior_L 18 55.1118 3.74787 608
Thalamic_Radiation_Superior_R 17 55.1917 3.63259 572
Cingulum_Frontal_Parahippocampal_R 15 58.8151 3.4159 539
Corticopontine_Tract_Occipital_L 11 58.3899 2.53628 295
Corticostriatal_Tract_Anterior_R 11 54.1962 3.5353 532
Anterior_Commissure 11 51.8178 3.15069 404
Corticopontine_Tract_Occipital_R 10 56.62 2.73237 332



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop Angular error rad3 in peri and post menopausal women


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop angular error rad3 in peri and post menopausal women


Glass Brain displaying tracts that had QA positively and negatively correlated with loop angular error rad3 in peri and post menopausal women







MD

All subjects

Positive Correlations (FDR = 0.052632)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 14 54.0197 3.34248 474



Negative Correlations (FDR = 0.001083)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 385 56.2115 7.25851 2326
Fornix_L 359 55.8681 8.22718 2970
Thalamic_Radiation_Superior_L 21 54.4852 3.44885 509



Figures

Slice overlay image displaying ROIs with tracts that had MD positively correlated with loop Angular error rad3


Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop angular error rad3 in peri and post menopausal women


Glass Brain displaying tracts that had MD positively and negatively correlated with loop angular error rad3 in peri and post menopausal women







Men

Positive Correlations (FDR = 0.052789)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1565 58.822 9.85954 4491
Fornix_R 252 55.9948 7.25689 2316
Thalamic_Radiation_Superior_L 110 56.39 6.15898 1680
Thalamic_Radiation_Superior_R 11 57.0999 2.44914 269
Corpus_Callosum_Forceps_Major 10 53.2237 3.24436 440
Cerebellum_L 10 52.8089 2.50373 260



Negative Correlations (FDR = 1.000000)
Not significant



Figures

Slice overlay image displaying ROIs with tracts that had MD positively correlated with loop Angular error rad3 in men


Glass Brain displaying tracts that had MD positively correlated with loop angular error rad3 in peri and post menopausal women







Women

Positive Correlations (FDR = 1.000000)
Not significant



Negative Correlations (FDR = 0.000594)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 790 55.9141 9.18768 3707
Fornix_R 298 55.11 6.73613 1964
Corpus_Callosum_Tapetum 112 60.6023 6.4171 1960
Corpus_Callosum_Body 106 57.9578 5.31933 1288
Thalamic_Radiation_Superior_L 78 53.3173 5.43288 1236
Optic_Radiation_L 29 54.8945 3.35399 485
Cingulum_Frontal_Parietal_L 11 54.5619 1.51225 98
Corpus_Callosum_Forceps_Major 10 53.6157 2.34722 232



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop angular error rad3 women


Glass Brain displaying tracts that had MD negatively correlated with loop angular error rad3 in women







pre

Positive Correlations (FDR = 1.000000)
Not significant



Negative Correlations (FDR = 0.027414)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 593 60.8483 8.51618 3466
Fornix_R 229 57.3531 5.34522 1287
Cerebellum_R 63 54.2347 4.15111 734
Thalamic_Radiation_Superior_L 36 53.8466 3.98621 672
Corpus_Callosum_Body 36 64.507 4.33708 953
Corpus_Callosum_Tapetum 36 59.8425 4.25515 851
Corpus_Callosum_Forceps_Major 31 55.6306 4.18162 764
Cingulum_Frontal_Parietal_L 17 55.0485 1.72734 129



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop angular error rad3 pre menopausal women


Glass Brain displaying tracts that had MD negatively correlated with loop angular error rad3 in pre menopausal women







peri

Positive Correlations (FDR = 1.000000)
Not significant



Negative Correlations (FDR = 0.018769)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 136 61.3216 9.20066 4077
Corpus_Callosum_Forceps_Major 125 61.5881 10.2136 5046
Cerebellum_R 96 54.6717 8.23653 2913
Corpus_Callosum_Body 94 63.0077 8.48647 3564
Fornix_L 89 62.0309 6.68314 2176
Corticostriatal_Tract_Posterior_R 71 56.0654 7.4759 2461
Inferior_Longitudinal_Fasciculus_R 63 62.7407 7.7058 2926
Corpus_Callosum_Forceps_Minor 47 59.0682 6.8029 2147
Cerebellum_L 44 53.5571 6.30093 1670
Arcuate_Fasciculus_R 30 58.1423 5.17726 1224
Inferior_Fronto_Occipital_Fasciculus_L 26 60.3186 5.16947 1266
Inferior_Fronto_Occipital_Fasciculus_R 25 57.9908 4.96774 1124
Arcuate_Fasciculus_L 23 55.6588 4.4714 874
Thalamic_Radiation_Superior_L 23 58.2649 3.96659 720
Fornix_R 23 61.9287 3.69203 663
Dentatorubrothalamic_Tract_L 21 55.6267 4.9396 1066
Middle_Cerebellar_Peduncle 21 63.6313 4.1507 861
Inferior_Longitudinal_Fasciculus_L 19 59.3809 4.15976 807
Dentatorubrothalamic_Tract_R 16 58.7448 3.74475 647
Optic_Radiation_L 14 55.7199 3.83613 644
Anterior_Commissure 14 57.5897 3.66635 608
Corticostriatal_Tract_Posterior_L 13 57.4001 3.65424 602
Thalamic_Radiation_Posterior_R 11 54.8985 3.79813 622
Reticular_Tract_L 11 64.9192 2.82183 406
Cingulum_Frontal_Parietal_L 10 61.3974 2.95475 421
Superior_Longitudinal_Fasciculus2_L 10 59.0103 3.38803 532
Corticospinal_Tract_L 10 53.4043 3.26818 448



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop angular error rad3 peri menopausal women


Glass Brain displaying tracts that had MD negatively correlated with loop angular error rad3 in peri menopausal women







post

Positive Correlations (FDR = 1.000000)

No Significant Findings



Negative Correlations (FDR = 0.289057)

No Significant Findings

Peri + Post

Positive Correlations (FDR = 1.000000)

No Significant Findings



Negative Correlations (FDR = 0.187319)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 923 57.9248 10.231 4762
Corpus_Callosum_Tapetum 860 60.3349 12.8388 7811
Fornix_R 305 56.5731 7.42714 2451
Cerebellum_R 143 53.405 7.3744 2281
Corpus_Callosum_Body 124 59.1681 7.52153 2629
Thalamic_Radiation_Superior_L 115 58.4374 6.05373 1682
Corpus_Callosum_Forceps_Major 114 58.4289 7.64203 2680
Inferior_Longitudinal_Fasciculus_R 45 56.8591 5.2503 1231
Inferior_Fronto_Occipital_Fasciculus_L 31 54.8414 4.20885 763
Corticostriatal_Tract_Posterior_R 23 54.7086 4.0073 690
Inferior_Longitudinal_Fasciculus_L 20 53.5151 3.94463 654
Cingulum_Frontal_Parietal_L 16 55.1192 2.81892 344
Cingulum_Frontal_Parahippocampal_L 15 62.6689 3.68674 669
Middle_Cerebellar_Peduncle 15 53.2047 2.78883 325
Arcuate_Fasciculus_L 13 56.4665 2.93872 383
Optic_Radiation_L 10 54.6088 2.7485 324



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop angular error rad3 peri and post menopausal women

Glass Brain displaying tracts that had MD negatively correlated with loop angular error rad3 in peri and post menopausal women







RD

All subjects

Positive Correlations (FDR = 0.050000)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 14 53.7203 3.04421 391



Negative Correlations (FDR = 0.000506)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 389 55.8954 6.84517 2057
Fornix_L 361 56.3367 7.97908 2817
Thalamic_Radiation_Superior_L 16 53.3834 2.84349 339



Figures

Slice overlay image displaying ROIs with tracts that had RD negatively correlated with loop angular error rad3


Glass Brain displaying tracts that had AD positively and negatively correlated with loop angular error rad3 in women


Glass Brain displaying tracts that had RD negatively correlated with loop angular error rad3







Men

Positive Correlations (FDR = 0.040025)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1041 59.0382 8.75236 3552
Fornix_R 133 56.5103 5.64637 1415
Thalamic_Radiation_Superior_L 60 55.3754 5.18668 1170
Corpus_Callosum_Forceps_Major 11 51.8294 3.13079 399



Negative Correlations (FDR = 1.000000)

Not significant



Figures

Slice overlay image displaying ROIs with tracts that had RD positively correlated with loop Angular error rad3 in men


Glass Brain displaying tracts that had RD positively correlated with loop angular error rad3 in men







Women

Positive Correlations (FDR = 1.000000)

Not significant



Negative Correlations (FDR = 0.000631)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 803 56.0847 9.28072 3794
Fornix_R 324 54.8724 6.761 1970
Corpus_Callosum_Body 77 54.1434 5.49924 1286
Corpus_Callosum_Tapetum 56 59.6825 4.82883 1093
Thalamic_Radiation_Superior_L 50 53.7264 4.64389 910
Cingulum_Frontal_Parietal_L 17 54.8275 1.56153 105



Figures

Slice overlay image displaying ROIs with tracts that had RD negatively correlated with loop angular error rad3 in women


Glass Brain displaying tracts that had RD positively and negatively correlated with loop angular error rad3 in women







pre

Positive Correlations (FDR = 1.000000)

Not significant



Negative Correlations (FDR = 0.030260)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 637 60.8372 8.79263 3694
Fornix_R 258 57.824 5.78906 1522
Corpus_Callosum_Tapetum 36 58.8379 4.04203 755
Corpus_Callosum_Body 30 63.9396 3.80223 726
Corpus_Callosum_Forceps_Major 29 58.9119 4.25828 839
Cerebellum_R 28 53.5071 3.36199 475
Thalamic_Radiation_Superior_L 18 54.2306 3.03372 392
Cingulum_Frontal_Parietal_L 13 52.9322 1.85465 143



Figures

Slice overlay image displaying ROIs with tracts that had RD negatively correlated with loop angular error rad3 in pre-menopausal women


Glass Brain displaying tracts that had RD negatively correlated with loop angular error rad3 in pre-menopausalwomen







peri

Positive Correlations (FDR = 1.000000)

Not significant



Negative Correlations (FDR = 0.017967)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 128 60.2305 9.82567 4567
Corpus_Callosum_Forceps_Major 102 60.6943 9.13395 3977
Corpus_Callosum_Tapetum 98 61.7859 8.18626 3252
Fornix_L 94 62.3784 6.54864 2101
Cerebellum_R 68 54.0638 7.70528 2521
Corpus_Callosum_Forceps_Minor 63 57.4765 7.41798 2484
Cerebellum_L 52 53.2363 7.05992 2084
Fornix_R 26 59.4028 3.45215 556
Inferior_Longitudinal_Fasciculus_R 25 60.0235 5.08923 1221
Thalamic_Radiation_Posterior_R 22 54.6439 4.78587 983
Corticostriatal_Tract_Posterior_R 19 53.2758 4.93004 1017
Dentatorubrothalamic_Tract_L 19 57.056 4.15599 774
Arcuate_Fasciculus_R 16 55.5145 4.2296 780
Thalamic_Radiation_Superior_L 15 63.0769 3.66104 664
Middle_Cerebellar_Peduncle 14 60.8666 3.74092 669
Reticular_Tract_R 13 57.087 3.24113 471
Reticular_Tract_L 12 62.4961 3.26422 523
Cingulum_Parolfactory_R 10 65.8215 2.12755 234
Corticospinal_Tract_L 10 57.4239 2.72947 336



Figures

Slice overlay image displaying ROIs with tracts that had RD negatively correlated with loop angular error rad3 in perimenopausal women


Glass Brain displaying tracts that had RD negatively correlated with loop angular error rad3 in peri menopausal women







post

Positive Correlations (FDR = 1.000000) No Significant Findings



Negative Correlations (FDR = 0.273451)

No Significant Findings







Peri + Post

Positive Correlations (FDR = 1.000000)

No significant



Negative Correlations (FDR = 0.231903)

No significant







Loop Angular error average

QA

All subjects

Positive Correlations (FDR = 0.001274)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 526 54.6692 10.5963 4821



Negative Correlations (FDR= 0.009901)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corticospinal_Tract_R 103 54.0583 6.05964 1559
Corpus_Callosum_Forceps_Major 30 56.5333 4.0603 732
Cerebellum_R 24 52.5 3.76985 586
Medial_Lemniscus_R 20 55 3.50607 531
Arcuate_Fasciculus_L 15 53.6 3.57158 537
Cingulum_Frontal_Parietal_L 12 52.6667 2.36316 231



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop Angular Error average


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop Angular Error average


Glass Brain displaying tracts that had QA positively and negatively correlated with loop Angular Error average





Men

Positive Correlations (FDR =0.249739)

not significant



Negative Correlations (FDR =0.038326)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 897 53.5295 15.2894 9828
Corpus_Callosum_Forceps_Major 330 59.697 8.26011 3199
Cerebellum_R 263 53.3308 9.28881 3614
Corpus_Callosum_Tapetum 77 58.9091 5.70148 1504
Vermis 64 52.7812 5.23716 1137
Arcuate_Fasciculus_L 26 57.6154 4.27761 828
Cingulum_Frontal_Parietal_R 6 53.6667 2.1783 200



Figures

Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop angular error average


Glass Brain displaying tracts that had QA negatively correlated with loop angular error average




Women

Positive Correlations (FDR =0.009950)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 62 52.3548 6.58864 1785
Cerebellum_L 57 53.9298 4.75083 956
Corpus_Callosum_Forceps_Major 25 55.2 3.92237 667



Negative Correlations (FDR = 0.001003)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corticospinal_Tract_R 611 56.3011 10.0261 4445
Medial_Lemniscus_R 278 57.0647 7.33297 2410
Corticostriatal_Tract_Superior_R 61 53.9344 5.36443 1219
Dentatorubrothalamic_Tract_R 55 52.2545 5.39606 1195
Cingulum_Frontal_Parietal_L 44 53.5455 3.36432 476
Corpus_Callosum_Tapetum 43 52.5581 5.31477 1166
Arcuate_Fasciculus_R 37 54.3784 3.81011 620
Corticospinal_Tract_L 29 56 4.65243 952
Corpus_Callosum_Body 29 54.8276 4.91678 1041
Corpus_Callosum_Forceps_Major 29 55.8621 3.74703 616
Extreme_Capsule_R 21 54.8571 2.88257 358
Inferior_Fronto_Occipital_Fasciculus_L 12 52.1667 2.62816 283
Extreme_Capsule_L 10 53.2 2.58868 280



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop angular error average


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop angular error average


Glass Brain displaying tracts that had QA positively and negatively correlated with loop angular error average









pre

Positive Correlations (FDR = 0.057417)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 771 62.4971 11.3668 6342
Corpus_Callosum_Tapetum 478 54.7222 11.6298 5813
Corpus_Callosum_Body 402 60.5216 9.15962 3988
Cerebellum_L 302 56.325 8.817 3439
Corpus_Callosum_Forceps_Minor 169 58.1751 6.87565 2160
Fornix_L 82 56.7185 4.75689 1008
Inferior_Longitudinal_Fasciculus_L 73 58.3937 6.6792 2046
Arcuate_Fasciculus_L 61 54.697 3.93741 666
Inferior_Fronto_Occipital_Fasciculus_L 47 54.697 5.81576 1453
Fornix_R 35 53.7272 3.21809 437
Corticostriatal_Tract_Posterior_L 24 52.5179 4.4939 833
Inferior_Longitudinal_Fasciculus_R 15 52.2904 3.35764 463
Thalamic_Radiation_Posterior_L 12 52.3479 3.08385 391
Cerebellum_R 11 57.0929 2.82162 357



Negative Correlations (FDR = 0.019934)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 771 62.4971 11.3668 6342
Corpus_Callosum_Tapetum 478 54.7222 11.6298 5813
Corpus_Callosum_Body 402 60.5216 9.15962 3988
Cerebellum_L 302 56.325 8.817 3439
Corpus_Callosum_Forceps_Minor 169 58.1751 6.87565 2160
Fornix_L 82 56.7185 4.75689 1008
Inferior_Longitudinal_Fasciculus_L 73 58.3937 6.6792 2046
Arcuate_Fasciculus_L 61 54.697 3.93741 666
Inferior_Fronto_Occipital_Fasciculus_L 47 54.697 5.81576 1453
Fornix_R 35 53.7272 3.21809 437
Corticostriatal_Tract_Posterior_L 24 52.5179 4.4939 833
Inferior_Longitudinal_Fasciculus_R 15 52.2904 3.35764 463
Thalamic_Radiation_Posterior_L 12 52.3479 3.08385 391
Cerebellum_R 11 57.0929 2.82162 357



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with loop angular error average


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop angular error average


Glass Brain displaying tracts that had QA positively and negatively correlated with loop angular error average









peri

Positive Correlations (FDR =0.530855)

Not significant

Negative Correlations (FDR = 0.010149)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 317 65.6593 15.7849 12849
Cerebellum_L 260 55.7538 14.3523 9020
Corpus_Callosum_Tapetum 213 63.8592 12.3744 7680
Inferior_Fronto_Occipital_Fasciculus_R 199 63.4271 10.7688 5777
Middle_Cerebellar_Peduncle 183 61.5956 12.0152 6984
Cerebellum_R 178 54.573 13.2554 7531
Corpus_Callosum_Forceps_Major 176 61.0909 11.5367 6386
Arcuate_Fasciculus_R 169 68.5562 9.87911 5255
Superior_Longitudinal_Fasciculus2_R 160 64.6 10.2543 5335
Corticospinal_Tract_R 139 65.7698 9.72465 4885
Cingulum_Frontal_Parietal_R 123 65.8211 7.8443 3181
Arcuate_Fasciculus_L 121 58.1322 10.468 5003
Corticostriatal_Tract_Posterior_R 113 65.4513 9.08837 4246
Inferior_Longitudinal_Fasciculus_L 96 61.7292 8.74894 3711
Inferior_Longitudinal_Fasciculus_R 90 61.2889 9.43715 4287
Inferior_Fronto_Occipital_Fasciculus_L 85 63.3882 8.40976 3521
Dentatorubrothalamic_Tract_R 79 59.9494 9.3849 4147
Medial_Lemniscus_R 77 64.1299 7.57878 2893
Superior_Longitudinal_Fasciculus2_L 76 60.2895 8.54692 3459
Corticostriatal_Tract_Posterior_L 70 62.2286 8.46966 3506
Frontal_Aslant_Tract_L 64 60.6562 7.9316 2997
Dentatorubrothalamic_Tract_L 63 58.4762 8.37584 3222
Corticostriatal_Tract_Superior_L 58 56.6207 7.71078 2644
Medial_Lemniscus_L 58 58.2069 6.57448 1976
Corticospinal_Tract_L 56 60.6786 7.35636 2579
Cingulum_Frontal_Parietal_L 53 60.7547 6.39595 1952
Corticopontine_Tract_Parietal_R 50 61.92 6.65368 2153
Thalamic_Radiation_Posterior_R 50 61.32 6.51311 2043
Vermis 49 55.3469 6.68739 1944
Corpus_Callosum_Forceps_Minor 44 57.3636 7.05746 2244
Cingulum_Parahippocampal_Parietal_R 37 57.2432 5.45329 1337
Corticostriatal_Tract_Superior_R 36 61.3889 6.49669 2035
Superior_Longitudinal_Fasciculus1_R 32 66.9375 5.18248 1412
Optic_Radiation_L 30 55.3333 4.90834 1047
Anterior_Commissure 30 65.6667 5.1521 1369
Corticopontine_Tract_Parietal_L 29 68.6897 5.50514 1635
Extreme_Capsule_R 27 63.1852 5.15549 1319
Thalamic_Radiation_Anterior_R 26 63.5385 4.99082 1243
Cingulum_Parolfactory_R 25 67.36 4.19497 931
Superior_Longitudinal_Fasciculus3_R 23 61.6522 4.78356 1108
Extreme_Capsule_L 22 60.2727 4.80293 1092
Thalamic_Radiation_Posterior_L 20 56.2 5.21842 1202
Parietal_Aslant_Tract_L 19 57.0526 4.80836 1036
Reticular_Tract_R 19 63.4737 4.88986 1192
Middle_Longitudinal_Fasciculus_R 18 58.3333 4.61789 977
Superior_Longitudinal_Fasciculus3_L 18 57.5556 4.45955 899
Parietal_Aslant_Tract_R 15 55.4667 3.88939 659
Corticopontine_Tract_Frontal_R 15 60.8 4.70924 1059
Corticopontine_Tract_Occipital_R 13 64.4615 3.38177 579
Thalamic_Radiation_Superior_R 13 61.3846 4.28931 887
Frontal_Aslant_Tract_R 12 53.3333 3.92406 645
Fornix_R 12 69.8333 3.07318 518
Middle_Longitudinal_Fasciculus_L 11 55.8182 3.80287 634
Reticular_Tract_L 10 60.4 3.75254 668



Figures

Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop angular error average


Glass Brain displaying tracts that had QA positively and negatively correlated with loop angular error average









post

Positive Correlations (FDR= 1.000000)



Negative Correlations (FDR =0.129906)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 2830 69.711 27.605 41722
Corpus_Callosum_Forceps_Minor 1108 68.9404 17.8293 17212
Corpus_Callosum_Forceps_Major 1068 78.3296 16.4186 16584
Arcuate_Fasciculus_L 790 71.4228 15.1864 12937
Corpus_Callosum_Tapetum 637 67.0769 16.063 13593
Cerebellum_R 536 57.6604 17.0805 13212
Corticospinal_Tract_R 383 65.0653 11.6721 6962
Inferior_Longitudinal_Fasciculus_L 284 68.6127 11.8624 7583
Inferior_Fronto_Occipital_Fasciculus_L 273 71.6337 11.4686 7400
Superior_Longitudinal_Fasciculus2_L 270 62.6889 12.4429 7623
Cingulum_Frontal_Parietal_L 264 69.7879 9.97979 5459
Middle_Cerebellar_Peduncle 263 60.4411 12.9273 7933
Inferior_Fronto_Occipital_Fasciculus_R 257 70.5214 11.2741 7040
Dentatorubrothalamic_Tract_R 231 61.6537 12.4735 7534
Cerebellum_L 220 55.3455 13.0502 7403
Medial_Lemniscus_R 219 63.8539 10.1198 5136
Corticostriatal_Tract_Posterior_L 215 67.8233 10.7772 6187
Corticospinal_Tract_L 176 62.3864 10.9854 5913
Dentatorubrothalamic_Tract_L 176 60.1364 11.8756 6661
Corticostriatal_Tract_Posterior_R 173 59.896 10.7061 5392
Cingulum_Frontal_Parietal_R 171 65.6491 9.32241 4481
Corticostriatal_Tract_Superior_L 156 58.9359 10.9647 5565
Extreme_Capsule_L 148 66.7703 8.98012 4229
Medial_Lemniscus_L 146 63.7123 9.13532 4176
Inferior_Longitudinal_Fasciculus_R 144 60.25 11.2641 6004
Superior_Longitudinal_Fasciculus2_R 144 60.7639 11.409 6212
Frontal_Aslant_Tract_L 131 64.626 10.3564 5444
Corticostriatal_Tract_Superior_R 128 58.9219 9.61024 4274
Parietal_Aslant_Tract_L 122 60.1803 7.56644 2706
Arcuate_Fasciculus_R 110 60.8727 8.92701 3810
Thalamic_Radiation_Posterior_L 106 60.5283 8.47437 3414
Middle_Longitudinal_Fasciculus_L 97 62.3918 7.7996 2981
Middle_Longitudinal_Fasciculus_R 93 64.7957 7.08145 2552
Thalamic_Radiation_Anterior_R 90 64.1778 8.57 3702
Frontal_Aslant_Tract_R 74 60.7568 8.1852 3197
Corticopontine_Tract_Parietal_R 70 66.4 6.58302 2260
Superior_Longitudinal_Fasciculus3_L 67 65.1642 7.1794 2638
Corticopontine_Tract_Parietal_L 65 65.0154 7.03059 2524
Extreme_Capsule_R 63 63.4603 6.45539 2077
Thalamic_Radiation_Posterior_R 61 62.4262 7.14071 2500
Superior_Longitudinal_Fasciculus1_L 56 63 5.97082 1764
Thalamic_Radiation_Anterior_L 53 59.6981 7.09465 2360
Superior_Longitudinal_Fasciculus3_R 50 58.88 6.82011 2151
Thalamic_Radiation_Superior_L 50 63.88 7.58571 2887
Parietal_Aslant_Tract_R 49 56.3265 6.26431 1736
Superior_Longitudinal_Fasciculus1_R 48 57.7917 5.92978 1596
Thalamic_Radiation_Superior_R 48 62.8333 6.95628 2388
Reticular_Tract_R 48 61.7917 6.83615 2268
Fornix_L 44 58.4091 6.71576 2069
Cingulum_Parolfactory_R 43 65.0233 4.77621 1165
Uncinate_Fasciculus_R 40 67.25 4.99725 1319
Reticular_Tract_L 39 59.0256 5.71476 1514
Cingulum_Parahippocampal_Parietal_R 38 61.7895 4.97058 1199
Corticostriatal_Tract_Anterior_R 35 54.4 6.3706 1734
Corticostriatal_Tract_Anterior_L 32 55 6.21773 1670
Cingulum_Frontal_Parahippocampal_L 30 69.8 5.32075 1552
Cingulum_Parolfactory_L 26 58.6154 5.13098 1212
Anterior_Commissure 26 58.3846 5.48388 1379
Superior_Cerebellar_Peduncle 26 58 4.48669 917
Cingulum_Parahippocampal_Parietal_L 24 57.4167 4.49218 910
Fornix_R 22 58.6364 3.43693 544
Cingulum_Frontal_Parahippocampal_R 16 61 3.36349 542
Corticopontine_Tract_Occipital_R 14 66 3.65109 691
Inferior_Cerebellar_Peduncle_L 14 55.2857 3.31442 477
Corticopontine_Tract_Occipital_L 12 59.5 3.53208 583
Corticopontine_Tract_Frontal_L 10 55.8 3.5329 547
Optic_Radiation_L 10 52.6 3.61542 540



Figures

Slice overlay image displaying ROIs with tracts that had QA negatively correlated with loop angular error average


Glass Brain displaying tracts that had QA negatively correlated with loop angular error average









Peri and Post

Positive Correlations (FDR =0.007092)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 2830 69.711 27.605 41722
Corpus_Callosum_Forceps_Minor 1108 68.9404 17.8293 17212
Corpus_Callosum_Forceps_Major 1068 78.3296 16.4186 16584
Arcuate_Fasciculus_L 790 71.4228 15.1864 12937
Corpus_Callosum_Tapetum 637 67.0769 16.063 13593
Cerebellum_R 536 57.6604 17.0805 13212
Corticospinal_Tract_R 383 65.0653 11.6721 6962
Inferior_Longitudinal_Fasciculus_L 284 68.6127 11.8624 7583
Inferior_Fronto_Occipital_Fasciculus_L 273 71.6337 11.4686 7400
Superior_Longitudinal_Fasciculus2_L 270 62.6889 12.4429 7623
Cingulum_Frontal_Parietal_L 264 69.7879 9.97979 5459
Middle_Cerebellar_Peduncle 263 60.4411 12.9273 7933
Inferior_Fronto_Occipital_Fasciculus_R 257 70.5214 11.2741 7040
Dentatorubrothalamic_Tract_R 231 61.6537 12.4735 7534
Cerebellum_L 220 55.3455 13.0502 7403
Medial_Lemniscus_R 219 63.8539 10.1198 5136
Corticostriatal_Tract_Posterior_L 215 67.8233 10.7772 6187
Corticospinal_Tract_L 176 62.3864 10.9854 5913
Dentatorubrothalamic_Tract_L 176 60.1364 11.8756 6661
Corticostriatal_Tract_Posterior_R 173 59.896 10.7061 5392
Cingulum_Frontal_Parietal_R 171 65.6491 9.32241 4481
Corticostriatal_Tract_Superior_L 156 58.9359 10.9647 5565
Extreme_Capsule_L 148 66.7703 8.98012 4229
Medial_Lemniscus_L 146 63.7123 9.13532 4176
Inferior_Longitudinal_Fasciculus_R 144 60.25 11.2641 6004
Superior_Longitudinal_Fasciculus2_R 144 60.7639 11.409 6212
Frontal_Aslant_Tract_L 131 64.626 10.3564 5444
Corticostriatal_Tract_Superior_R 128 58.9219 9.61024 4274
Parietal_Aslant_Tract_L 122 60.1803 7.56644 2706
Arcuate_Fasciculus_R 110 60.8727 8.92701 3810
Thalamic_Radiation_Posterior_L 106 60.5283 8.47437 3414
Middle_Longitudinal_Fasciculus_L 97 62.3918 7.7996 2981
Middle_Longitudinal_Fasciculus_R 93 64.7957 7.08145 2552
Thalamic_Radiation_Anterior_R 90 64.1778 8.57 3702
Frontal_Aslant_Tract_R 74 60.7568 8.1852 3197
Corticopontine_Tract_Parietal_R 70 66.4 6.58302 2260
Superior_Longitudinal_Fasciculus3_L 67 65.1642 7.1794 2638
Corticopontine_Tract_Parietal_L 65 65.0154 7.03059 2524
Extreme_Capsule_R 63 63.4603 6.45539 2077
Thalamic_Radiation_Posterior_R 61 62.4262 7.14071 2500
Superior_Longitudinal_Fasciculus1_L 56 63 5.97082 1764
Thalamic_Radiation_Anterior_L 53 59.6981 7.09465 2360
Superior_Longitudinal_Fasciculus3_R 50 58.88 6.82011 2151
Thalamic_Radiation_Superior_L 50 63.88 7.58571 2887
Parietal_Aslant_Tract_R 49 56.3265 6.26431 1736
Superior_Longitudinal_Fasciculus1_R 48 57.7917 5.92978 1596
Thalamic_Radiation_Superior_R 48 62.8333 6.95628 2388
Reticular_Tract_R 48 61.7917 6.83615 2268
Fornix_L 44 58.4091 6.71576 2069
Cingulum_Parolfactory_R 43 65.0233 4.77621 1165
Uncinate_Fasciculus_R 40 67.25 4.99725 1319
Reticular_Tract_L 39 59.0256 5.71476 1514
Cingulum_Parahippocampal_Parietal_R 38 61.7895 4.97058 1199
Corticostriatal_Tract_Anterior_R 35 54.4 6.3706 1734
Corticostriatal_Tract_Anterior_L 32 55 6.21773 1670
Cingulum_Frontal_Parahippocampal_L 30 69.8 5.32075 1552
Cingulum_Parolfactory_L 26 58.6154 5.13098 1212
Anterior_Commissure 26 58.3846 5.48388 1379
Superior_Cerebellar_Peduncle 26 58 4.48669 917
Cingulum_Parahippocampal_Parietal_L 24 57.4167 4.49218 910
Fornix_R 22 58.6364 3.43693 544
Cingulum_Frontal_Parahippocampal_R 16 61 3.36349 542
Corticopontine_Tract_Occipital_R 14 66 3.65109 691
Inferior_Cerebellar_Peduncle_L 14 55.2857 3.31442 477
Corticopontine_Tract_Occipital_L 12 59.5 3.53208 583
Corticopontine_Tract_Frontal_L 10 55.8 3.5329 547
Optic_Radiation_L 10 52.6 3.61542 540



Negative Correlations (FDR = 0.000492)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 226 56.0531 8.72584 3352
Middle_Cerebellar_Peduncle 43 55.5814 5.07201 1123
Inferior_Longitudinal_Fasciculus_R 19 53.0526 3.23478 436
Cingulum_Parolfactory_L 16 54.875 2.05496 182
Inferior_Fronto_Occipital_Fasciculus_R 12 52.3333 3.45978 492
Corpus_Callosum_Body 11 54.1818 3.18986 433
Cingulum_Parolfactory_R 10 54.8 1.73795 130



Figures








<b

MD

All subjects

Positive Correlations (FDR =0.494235)

Not Significant

Negative Correlations (FDR = 0.211694)

Not significant







Men

Positive Correlations (FDR = 0.012952)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1963 58.0856 10.7612 5283
Fornix_R 310 55.1097 7.86733 2679
Thalamic_Radiation_Superior_L 198 55.2525 7.42592 2393
Corpus_Callosum_Forceps_Major 148 58.7297 6.05477 1691
Cerebellum_L 38 52.5263 3.67776 558
Thalamic_Radiation_Posterior_L 21 53.7143 3.92826 651
Thalamic_Radiation_Superior_R 13 55.6923 2.61453 299



Negative Correlations (FDR = 0.842857)

Not significant



Figures

Slice overlay image displaying ROIs with tracts that had MD positively correlated with loop angular error average


Glass Brain displaying tracts that had MD positively correlated with loop angular error average









Women

Positive Correlations (FDR = 1.000000)

Not significant



Negative Correlations (FDR = 0.020210)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1745 57.9862 11.0054 5516
Fornix_R 644 56.4255 8.47093 3180
Thalamic_Radiation_Superior_L 221 56.3348 7.35578 2394
Corpus_Callosum_Tapetum 179 57.229 8.15473 2989
Corpus_Callosum_Body 130 59.4769 7.46049 2600
Cingulum_Frontal_Parietal_L 115 59.1478 4.70187 1027
Uncinate_Fasciculus_R 62 57.2903 4.3642 857
Corpus_Callosum_Forceps_Major 44 57.5454 4.02718 733
Cerebellum_R 29 51.4483 3.74925 568
Thalamic_Radiation_Superior_R 17 52.4706 3.55904 522
Thalamic_Radiation_Anterior_L 15 58.5333 2.76317 351
Optic_Radiation_L 10 52 2.26758 210



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop angular error average


Glass Brain displaying tracts that had MD negatively correlated with loop angular error average









pre

Positive Correlations (FDR = 1.000000)

Not significant



Negative Correlations (FDR = 0.065391)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 786 61.5242 8.65897 3623
Fornix_R 213 57.3052 5.41968 1322
Cerebellum_R 130 55.8461 5.92734 1541
Corpus_Callosum_Forceps_Major 61 60.3934 5.0109 1191
Optic_Radiation_L 41 55.6097 4.01767 705
Thalamic_Radiation_Superior_L 30 54.2 3.27294 456
Corpus_Callosum_Tapetum 29 56.2759 4.40336 857
Cingulum_Frontal_Parietal_L 10 54.4 1.6689 119
Inferior_Fronto_Occipital_Fasciculus_L 10 58.2 2.68689 330



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop angular error average


Glass Brain displaying tracts that had MD negatively correlated with loop angular error average









peri

Positive Correlations (FDR =1.000000)

Not significant



Negative Correlations (FDR = 0.004145)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 129 61.2093 8.94091 3843
Corpus_Callosum_Forceps_Major 119 61.563 10.0329 4867
Cerebellum_R 89 54.5843 8.37367 3006
Corpus_Callosum_Body 81 63.5556 7.97912 3178
Corticostriatal_Tract_Posterior_R 69 55.6522 7.37753 2379
Fornix_L 64 63.8438 6.07902 1853
Inferior_Longitudinal_Fasciculus_R 63 63.8095 7.46397 2792
Cerebellum_L 54 53.1481 6.38356 1701
Corpus_Callosum_Forceps_Minor 38 58.6316 6.34176 1852
Arcuate_Fasciculus_R 28 58.6429 5.04227 1171
Inferior_Fronto_Occipital_Fasciculus_R 28 59.2143 4.90082 1117
Arcuate_Fasciculus_L 26 55.4615 4.48191 875
Inferior_Fronto_Occipital_Fasciculus_L 26 60.0769 5.17986 1266
Dentatorubrothalamic_Tract_L 19 57.0526 4.44164 884
Inferior_Longitudinal_Fasciculus_L 17 59.1765 4.1824 813
Fornix_R 17 59.6471 3.1607 468
Middle_Cerebellar_Peduncle 16 63.125 3.71435 684
Dentatorubrothalamic_Tract_R 13 59.3846 3.55667 590
Anterior_Commissure 13 57.2308 3.85504 668
Thalamic_Radiation_Superior_L 12 57.1667 3.52534 558
Superior_Longitudinal_Fasciculus2_L 11 58.5454 3.41103 535
Corticospinal_Tract_L 11 53.2727 3.2539 443
Optic_Radiation_L 11 55.4545 3.61445 569
Superior_Longitudinal_Fasciculus2_R 10 56 3.57143 561
Corticostriatal_Tract_Posterior_L 10 56.4 3.30892 485



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop angular error average


Glass Brain displaying tracts that had MD negatively correlated with loop angular error average









post

Positive Correlations (FDR = 1.000000)

Not significant



Negative Correlations (FDR = 0.028462)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 145 55.4897 11.2747 5540
Fornix_L 96 58.3125 6.09792 1703
Corpus_Callosum_Tapetum 69 60.058 7.13899 2404
Corpus_Callosum_Forceps_Major 59 65.0508 7.2696 2700
Cerebellum_L 50 55.76 6.51704 1860
Arcuate_Fasciculus_L 38 54.3158 5.38489 1237
Corticostriatal_Tract_Posterior_R 38 60.3684 5.77635 1582
Superior_Longitudinal_Fasciculus2_R 31 59.871 5.84595 1607
Corpus_Callosum_Body 31 55.0323 6.28991 1710
Inferior_Longitudinal_Fasciculus_R 26 60.7692 5.54028 1465
Arcuate_Fasciculus_R 24 58 4.89837 1093
Middle_Cerebellar_Peduncle 23 59.5652 5.24503 1287
Fornix_R 22 58.8182 3.06156 433
Inferior_Fronto_Occipital_Fasciculus_R 20 55.4 4.33588 818
Thalamic_Radiation_Superior_L 16 57 3.57763 573
Inferior_Longitudinal_Fasciculus_L 13 54.1538 3.88818 643
Corticopontine_Tract_Parietal_R 13 58.6154 3.84329 680
Corpus_Callosum_Forceps_Minor 12 53.6667 3.73818 589
Corticospinal_Tract_R 11 61.4545 3.33864 538



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop angular error average


Glass Brain displaying tracts that had MD negatively correlated with loop angular error average









Peri and Post

Positive Correlations (FDR = 0.168126)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 409 58.2836 9.84303 4435
Fornix_L 392 55.7041 8.13459 2895
Cerebellum_R 176 55.125 7.46706 2414
Thalamic_Radiation_Superior_L 72 58.0556 4.92728 1107
Corpus_Callosum_Body 48 62.7917 5.15788 1312
Corpus_Callosum_Forceps_Major 29 54.3448 4.07567 709
Optic_Radiation_L 28 54.7143 3.70536 590
Inferior_Fronto_Occipital_Fasciculus_L 16 55.125 3.06227 406
Fornix_R 16 51 3.58918 516



Negative Correlations (FDR = 0.150048)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 409 58.2836 9.84303 4435
Fornix_L 392 55.7041 8.13459 2895
Cerebellum_R 176 55.125 7.46706 2414
Thalamic_Radiation_Superior_L 72 58.0556 4.92728 1107
Corpus_Callosum_Body 48 62.7917 5.15788 1312
Corpus_Callosum_Forceps_Major 29 54.3448 4.07567 709
Optic_Radiation_L 28 54.7143 3.70536 590
Inferior_Fronto_Occipital_Fasciculus_L 16 55.125 3.06227 406
Fornix_R 16 51 3.58918 516



Figures

Slice overlay image displaying ROIs with tracts that had MD positively correlated with loop angular error average


Slice overlay image displaying ROIs with tracts that had MD negatively correlated with loop angular error average


Glass Brain displaying tracts that had MD positively and negatively correlated with loop angular error average









AD

All subjects

Positive Correlations (FDR =0.414365)

Not significant

Negative Correlations (FDR =0.170648)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 258 56.2403 5.21872 1203
Fornix_L 55 54.5455 4.11382 725



Figures









Men

Positive Correlations (FDR =0.0033520)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 2073 56.6097 11.1111 5489
Fornix_R 519 55.0096 9.05568 3543
Thalamic_Radiation_Superior_L 472 55.8263 8.8305 3419
Corpus_Callosum_Forceps_Major 182 55.4506 5.9965 1566
Cerebellum_L 104 52.1538 5.3399 1168
Cingulum_Frontal_Parietal_L 85 59.6706 5.08961 1214
Thalamic_Radiation_Posterior_L 50 54 4.97805 1051
Thalamic_Radiation_Anterior_L 25 52.32 3.38916 472
Thalamic_Radiation_Superior_R 11 54.3636 3.25724 453



Negative Correlations (FDR =1.000000)











Women

Positive Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 24 52.0833 3.2157 423
Cerebellum_L 13 54 3.15064 421



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 853 55.6764 8.71604 3322
Fornix_R 182 54.1758 5.93544 1499
Thalamic_Radiation_Superior_L 167 55.3054 6.86484 2047
Cingulum_Frontal_Parietal_L 87 58.8966 4.62857 991
Optic_Radiation_L 27 55.7778 3.19432 447
Cerebellum_R 18 51.5555 2.95678 354
Inferior_Fronto_Occipital_Fasciculus_L 14 53.7143 3.12885 413
Thalamic_Radiation_Anterior_L 12 56.5 2.73527 332



Figures









pre

Positive Correlations (FDR = )



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 880 59.1159 9.69272 4362
Cerebellum_R 323 56.6502 9.27314 3826
Fornix_R 272 57.9265 6.89835 2165
Corpus_Callosum_Forceps_Major 85 59.4588 6.61588 2044
Thalamic_Radiation_Superior_L 70 55.5143 5.23962 1197
Corpus_Callosum_Tapetum 43 55.814 4.7929 1007
Optic_Radiation_L 40 54.55 4.25587 776
Thalamic_Radiation_Superior_R 22 55.6364 3.04817 406
Corticospinal_Tract_L 18 56.2222 3.00599 399
Cingulum_Frontal_Parietal_L 15 58.2667 3.40316 530
Optic_Radiation_R 10 52.2 2.34787 226



Figures









peri

Positive Correlations (FDR = )



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 187 67.861 10.1732 5516
Cerebellum_R 106 54.2264 8.8411 3329
Corpus_Callosum_Forceps_Major 85 62.2824 8.06914 3185
Cerebellum_L 63 53.9365 6.68657 1894
Fornix_L 56 60.4643 5.79725 1596
Corpus_Callosum_Body 50 59.24 6.84504 2180
Inferior_Longitudinal_Fasciculus_L 37 56.0541 5.5519 1357
Arcuate_Fasciculus_R 36 63.6111 5.10694 1303
Middle_Cerebellar_Peduncle 35 54.6857 5.50161 1300
Corticostriatal_Tract_Posterior_R 34 57.7059 6.30554 1802
Inferior_Fronto_Occipital_Fasciculus_R 31 56.6452 5.872 1534
Dentatorubrothalamic_Tract_R 26 60.9231 5.54083 1469
Inferior_Longitudinal_Fasciculus_R 25 59.2 5.50295 1408
Corticospinal_Tract_R 25 61.84 4.3829 933
Corticospinal_Tract_L 20 58.9 4.21022 820
Fornix_R 20 69.2 3.41005 632
Inferior_Fronto_Occipital_Fasciculus_L 19 59.6842 4.53956 966
Optic_Radiation_L 19 59.8947 4.51277 958
Corticopontine_Tract_Parietal_L 18 61.1111 3.45519 573
Dentatorubrothalamic_Tract_L 18 56.3333 4.43946 872
Arcuate_Fasciculus_L 16 59.5 4.34933 884
Corticostriatal_Tract_Posterior_L 16 55.5 4.11747 739
Cingulum_Parolfactory_R 15 62.8 3.633 651
Thalamic_Radiation_Posterior_L 14 57.4286 4.22988 807
Medial_Lemniscus_R 14 63.8571 3.57224 640
Superior_Longitudinal_Fasciculus2_L 13 55.5385 3.44273 517
Thalamic_Radiation_Posterior_R 13 58.3077 4.0144 738
Thalamic_Radiation_Anterior_R 12 52.8333 3.41879 485
Corpus_Callosum_Forceps_Minor 12 59.5 3.5472 588
Anterior_Commissure 11 58.5454 3.29427 499
Corticopontine_Tract_Parietal_R 10 56 3.15572 438



Figures









post

Positive Correlations (FDR = )



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 98 55.8163 8.35342 3059
Cerebellum_L 41 53.6585 5.94006 1487
Fornix_L 37 57.4054 4.77966 1030
Corpus_Callosum_Tapetum 33 56.1818 5.62068 1394
Corpus_Callosum_Forceps_Major 27 60 5.19953 1274
Corticostriatal_Tract_Posterior_R 18 54.5556 4.41976 837
Thalamic_Radiation_Superior_L 16 60.625 3.04677 442
Fornix_R 16 58.625 3.10181 443
Corpus_Callosum_Body 15 58.2667 4.32496 856
Inferior_Longitudinal_Fasciculus_R 14 53.8571 3.95904 663
Cingulum_Parolfactory_R 11 54.5455 2.89483 359
Middle_Cerebellar_Peduncle 10 53.8 3.27787 454



Figures









Peri and Post

Positive Correlations (FDR = )



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 1226 59.8887 13.2501 8258
Fornix_L 501 55.0228 9.59557 3979
Cerebellum_R 364 54.9099 8.57623 3172
Corpus_Callosum_Forceps_Major 360 56.2382 9.18954 3730
Corpus_Callosum_Body 300 55.0351 7.54555 2461
Thalamic_Radiation_Superior_L 241 57.0684 8.15937 2984
Cingulum_Frontal_Parietal_L 128 59.4798 4.73417 1047
Inferior_Fronto_Occipital_Fasciculus_L 87 54.2143 6.16816 1620
Cerebellum_L 64 52.257 5.87166 1415
Optic_Radiation_L 60 53.641 5.47747 1264
Thalamic_Radiation_Anterior_L 33 53.0334 3.31599 458
Inferior_Longitudinal_Fasciculus_L 32 56.7611 4.56988 931
Cingulum_Parolfactory_R 30 54.6772 3.02131 392
Anterior_Commissure 25 58.5027 4.33885 865
Thalamic_Radiation_Superior_R 19 56.6408 3.38591 510
Arcuate_Fasciculus_L 13 67.5389 2.34622 292
Cingulum_Frontal_Parahippocampal_L 11 62.0182 3.3296 540
Thalamic_Radiation_Posterior_L 10 58.6093 3.18856 468



Figures













RD

All subjects

Positive Correlations (FDR = )

Not significant



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 423 55.8203 6.19769 1684
Fornix_L 183 55.7705 5.20569 1187
Corpus_Callosum_Body 18 50.3333 3.91205 605
Cingulum_Frontal_Parietal_L 10 56.8 1.92319 165



Figures









Men

Positive Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 3786 59.0951 11.996 6679
Fornix_R 656 55.1037 9.35803 3790
Thalamic_Radiation_Superior_L 433 56.8037 8.59137 3293
Corpus_Callosum_Forceps_Major 254 59.1732 6.93631 2236
Corpus_Callosum_Tapetum 47 55.4894 5.03992 1107
Cerebellum_L 45 51.9556 3.77335 581
Thalamic_Radiation_Posterior_L 44 54.8182 4.9759 1066
Cingulum_Frontal_Parietal_L 33 61.3333 4.06247 795
Thalamic_Radiation_Superior_R 20 55 3.2024 443
Cingulum_Frontal_Parahippocampal_L 15 63.8667 3.22901 523
Thalamic_Radiation_Anterior_L 14 52.1429 2.9276 351



Negative Correlations (FDR = )



Figures









Women

Positive Correlations (FDR = )



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 19 54.1065 3.50482 522



Figures









pre

Positive Correlations (FDR = )



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 19 54.1065 3.50482 522



Figures









peri

Positive Correlations (FDR = )



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 114 59.7895 9.42234 4169
Corpus_Callosum_Forceps_Major 109 59.8899 9.22049 3999
Corpus_Callosum_Tapetum 89 61.3483 8.1825 3226
Cerebellum_R 71 54 8.00834 2720
Fornix_L 65 62 6.00683 1757
Corpus_Callosum_Forceps_Minor 56 57.9643 7.16174 2335
Cerebellum_L 48 53.2917 6.83263 1954
Inferior_Longitudinal_Fasciculus_R 20 60.3 4.78422 1084
Corticostriatal_Tract_Posterior_R 20 53.3 4.69307 922
Thalamic_Radiation_Posterior_R 18 54.7778 4.45013 852
Fornix_R 17 56.4706 3.07363 419
Arcuate_Fasciculus_R 16 55.5 4.18654 764
Dentatorubrothalamic_Tract_L 14 56.8571 3.73514 623
Middle_Cerebellar_Peduncle 14 61.1429 3.71288 662
Reticular_Tract_R 12 56.1667 3.02626 404
Dentatorubrothalamic_Tract_R 11 53.0909 3.88392 629
Cingulum_Frontal_Parietal_L 10 58.8 3.29042 500
Cingulum_Parolfactory_R 10 65.4 2.16158 240
Corticospinal_Tract_L 10 57.6 2.66377 321



Figures









post

Positive Correlations (FDR = )



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 140 55.5429 10.6674 4964
Fornix_L 129 59.0078 6.64599 2047
Corpus_Callosum_Tapetum 59 61.9322 7.20204 2523
Cerebellum_L 56 56.5357 6.49822 1875
Corpus_Callosum_Body 54 56.8519 7.89051 2780
Middle_Cerebellar_Peduncle 51 58.5098 7.42288 2532
Corpus_Callosum_Forceps_Major 36 63.2222 6.52797 2116
Fornix_R 34 56.4118 3.75587 625
Corpus_Callosum_Forceps_Minor 34 55.2353 5.99281 1558
Inferior_Longitudinal_Fasciculus_R 29 58.1379 5.8768 1577
Dentatorubrothalamic_Tract_R 23 59.3913 5.3317 1326
Arcuate_Fasciculus_L 18 53.8889 4.81683 982
Corticospinal_Tract_R 18 62.5556 4.12007 834
Inferior_Fronto_Occipital_Fasciculus_R 17 57.5294 4.4556 897
Corticostriatal_Tract_Posterior_R 17 61.6471 4.67899 1060
Arcuate_Fasciculus_R 15 57.4667 4.34732 853
Superior_Longitudinal_Fasciculus2_R 14 62.8571 4.14942 850
Thalamic_Radiation_Superior_L 13 60.3077 3.61797 620
Dentatorubrothalamic_Tract_L 12 54.8333 3.80954 625
Corticospinal_Tract_L 11 55.6364 3.21621 452
Medial_Lemniscus_R 11 64 3.5766 643
Cingulum_Frontal_Parietal_R 10 61.8 3.6679 653
Frontal_Aslant_Tract_R 10 54.6 3.1221 418
Corticopontine_Tract_Parietal_R 10 59.6 3.34897 525



Figures









Peri and Post

Positive Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Middle_Cerebellar_Peduncle 318 55.1761 7.75175 2604
Cerebellum_R 295 54.0339 11.2583 5379
Inferior_Longitudinal_Fasciculus_L 234 55.6838 7.83689 2686
Cerebellum_L 217 52.9217 9.3838 3660
Corpus_Callosum_Tapetum 210 56.6476 11.019 5402
Fornix_L 209 57.3397 6.57691 1948
Corpus_Callosum_Forceps_Major 198 58.0303 10.1235 4671
Fornix_R 115 55.2348 6.54971 1861
Corpus_Callosum_Body 96 57.6667 7.64342 2646
Arcuate_Fasciculus_L 72 56.25 5.92324 1550
Thalamic_Radiation_Posterior_L 56 53.4286 5.10595 1094
Thalamic_Radiation_Superior_L 47 54.383 5.78213 1428
Optic_Radiation_L 36 55.2222 4.28674 797
Cingulum_Frontal_Parahippocampal_L 26 69.6154 4.26379 994
Vermis 26 53.7692 3.16489 423
Cingulum_Parahippocampal_Parietal_R 21 56 3.56825 560
Cingulum_Frontal_Parietal_L 19 66.2105 3.40526 603
Inferior_Fronto_Occipital_Fasciculus_L 19 52 3.93068 631
Thalamic_Radiation_Posterior_R 18 53.7778 3.76903 600
Inferior_Cerebellar_Peduncle_R 18 57 3.80163 647
Thalamic_Radiation_Anterior_L 17 54.5882 2.98886 383
Corticostriatal_Tract_Anterior_R 13 53.3846 2.51403 265
Cingulum_Frontal_Parietal_R 11 58.1818 3.18998 465



Negative Correlations (FDR = )
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 877 56.2144 9.69517 4150
Corpus_Callosum_Tapetum 632 57.5063 9.48113 4060
Cerebellum_R 244 55.0574 8.05978 2809
Thalamic_Radiation_Superior_L 146 58.0137 6.24502 1777
Corpus_Callosum_Forceps_Major 112 54.1786 6.20627 1639
Fornix_R 66 52.1818 5.50055 1240
Cingulum_Frontal_Parietal_L 60 59.3333 5.18332 1252
Corpus_Callosum_Forceps_Minor 54 55.037 5.05602 1105
Corpus_Callosum_Body 54 55.3333 5.53415 1331
Cerebellum_L 37 52.3243 5.92771 1444
Thalamic_Radiation_Anterior_L 19 54 3.06722 399
Cingulum_Frontal_Parietal_R 15 55.8667 3.27634 471
Uncinate_Fasciculus_R 15 53.2 3.12102 407
Dentatorubrothalamic_Tract_R 15 56.5333 2.81562 352
Cingulum_Frontal_Parahippocampal_L 14 61.8571 3.6634 652
Cingulum_Parolfactory_R 10 54.2 2.40882 247



Figures